Hybrid selection as a method of increasing mapping power for radiation hybrids.
نویسندگان
چکیده
منابع مشابه
Hybrid selection as a method of increasing mapping power for radiation hybrids.
Radiation hybrids have become a widely used tool for physical mapping. A drawback of the technique is that large numbers of hybrids are required to construct robust, high-resolution maps. The information contained within a panel of radiation hybrids is limited by the frequency of retention of chromosomal fragments from the donor cell line. In almost all experiments to date, the retention freque...
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15 صفحه اولStatistical methods for polyploid radiation hybrid mapping.
Radiation hybrid mapping is a somatic cell technique for ordering genetic loci along a chromosome and estimating physical distances between adjacent loci. This paper presents a model of fragment generation and retention for data involving two or more copies of the chromosome of interest per clone. Such polyploid data can be generated by initially irradiating normal diploid cells or by pooling h...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1996
ISSN: 1088-9051
DOI: 10.1101/gr.6.8.761